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Optical Tweezers Studies on Notch: Single-molecule Interaction Strength is Independent of Ligand Endocytosis
Notch signaling controls diverse cellular processes critical to development and disease. Cell surface ligands bind Notch on neighboring cells yet require endocytosis to activate signaling. The role ligand endocytosis plays in Notch activation has not been established. Here we integrate optical tweez...
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| Autores principales: | , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2012
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3376165/ https://ncbi.nlm.nih.gov/pubmed/22658935 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2012.04.007 |
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