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Adaptive Isotonic Estimation of the Minimum Effective and Peak Doses in the Presence of Covariates

We consider a problem of estimating the minimum effective and peak doses in the presence of covariates. We propose a sequential strategy for subject assignment that includes an adaptive randomization component to balance the allocation to placebo and active doses with respect to covariates. We concl...

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Detalhes bibliográficos
Main Authors: Xiao, Changfu, Ivanova, Anastasia
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3375738/
https://ncbi.nlm.nih.gov/pubmed/22711972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jspi.2012.01.024
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