Hypoxia Activates Tumor Suppressor p53 by Inducing ATR-Chk1 Kinase Cascade-mediated Phosphorylation and Consequent 14-3-3γ Inactivation of MDMX Protein

It has been known that p53 can be induced and activated by hypoxia, an abnormal condition that often occurs in rapidly growing solid tumors or when normal tissues undergo ischemia. Although the ATR-Chk1 kinase cascade was associated with hypoxia-induced p53 activation, molecules that directly link t...

وصف كامل

محفوظ في:
التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Lee, Jun-Ho, Jin, Yetao, He, Guifen, Zeng, Shelya X., Wang, Yunyuan V., Wahl, Geoffrey M., Lu, Hua
التنسيق: Artigo
اللغة:Inglês
منشور في: American Society for Biochemistry and Molecular Biology 2012
الموضوعات:
Signal Transduction
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC3375513/
https://ncbi.nlm.nih.gov/pubmed/22556425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.336875
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