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14-3-3γ binds to MDMX that is phosphorylated by UV-activated Chk1, resulting in p53 activation
It has been shown that MDMX inhibits the activity of the tumor suppressor p53 by primarily cooperating with the p53 feedback regulator MDM2. Here, our study shows that this inhibition can be overcome by 14-3-3γ and Chk1. 14-3-3γ was identified as an MDMX-associated protein via an immuno-affinity pur...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1422168/ https://ncbi.nlm.nih.gov/pubmed/16511572 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601010 |
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