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Characterization and Solubilization of Pyrrole–Imidazole Polyamide Aggregates

[Image: see text] To optimize the biological activity of pyrrole–imidazole polyamide DNA-binding molecules, we characterized the aggregation propensity of these compounds through dynamic light scattering and fractional solubility analysis. Nearly all studied polyamides were found to form measurable...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Hargrove, Amanda E., Raskatov, Jevgenij A., Meier, Jordan L., Montgomery, David C., Dervan, Peter B.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Chemical Society 2012
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3375050/
https://ncbi.nlm.nih.gov/pubmed/22607187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm300380a
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