Design and synthesis of gambogic acid analogs as potent cytotoxic and anti-inflammatory agents

Prenyl- and pyrano-xanthones derived from 1,3,6-trihydroxy-9H-xanthen-9-one, a basic backbone of gambogic acid (GA), were synthesized and evaluated for in vitro cytotoxic effects against four human cancer cell lines (KB, KBvin, A549, and DU-145) and anti-inflammatory activity toward superoxide anion...

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Main Authors: Yen, Chiao-Ting, Nakagawa-Goto, Kyoko, Hwang, Tsong-Long, Morris-Natschke, Susan L., Bastow, Kenneth F., Wu, Yang-Chang, Lee, Kuo-Hsiung
Formato: Artigo
Idioma:Inglês
Publicado: 2012
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3374489/
https://ncbi.nlm.nih.gov/pubmed/22595179
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2012.04.084
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