Lipid Nanoparticles for Hepatic Delivery of Small Interfering RNA

Clinical application of small interfering RNA (siRNA) requires safe and efficient delivery in vivo. Here, we report the design and synthesis of lipid nanoparticles (LNPs) for siRNA delivery based on cationic lipids with multiple tertiary amines and hydrophobic linoleyl chains. LNPs incorporating the...

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Detalhes bibliográficos
Main Authors: Yu, Bo, Hsu, Shu-Hao, Zhou, Chenguang, Wang, Xinmei, Terp, Megan Cavanaugh, Wu, Yun, Teng, Lesheng, Mao, Yicheng, Wang, Feng, Xue, Weiming, Jacob, Samson T., Ghoshal, Kalpana, Lee, Robert J., Lee, L. James
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3374058/
https://ncbi.nlm.nih.gov/pubmed/22652024
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biomaterials.2012.05.002
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