Lipid Nanoparticles for Hepatic Delivery of Small Interfering RNA

Clinical application of small interfering RNA (siRNA) requires safe and efficient delivery in vivo. Here, we report the design and synthesis of lipid nanoparticles (LNPs) for siRNA delivery based on cationic lipids with multiple tertiary amines and hydrophobic linoleyl chains. LNPs incorporating the...

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Detalles Bibliográficos
Autores principales: Yu, Bo, Hsu, Shu-Hao, Zhou, Chenguang, Wang, Xinmei, Terp, Megan Cavanaugh, Wu, Yun, Teng, Lesheng, Mao, Yicheng, Wang, Feng, Xue, Weiming, Jacob, Samson T., Ghoshal, Kalpana, Lee, Robert J., Lee, L. James
Formato: Artigo
Lenguaje:Inglês
Publicado: 2012
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3374058/
https://ncbi.nlm.nih.gov/pubmed/22652024
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biomaterials.2012.05.002
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