Enhanced hepatic delivery of siRNA and microRNA using oleic acid based lipid nanoparticle formulations

Many cationic lipids have been developed for lipid-based nanoparticles (LNPs) for delivery of siRNA and microRNA (miRNA). However, less attention has been paid to “helper lipids”. Here, we investigated several “helper lipids” and examined their effects on the physicochemical properties such as parti...

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Dettagli Bibliografici
Pubblicato in:J Control Release
Autori principali: Wang, Xinmei, Yu, Bo, Ren, Wei, Mo, Xiaokui, Zhou, Chenguang, He, Hongyan, Jia, HuLiang, Wang, Lu, Jacob, Samson T., Lee, Robert J., Ghoshal, Kalpana, Lee, L. James
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4307782/
https://ncbi.nlm.nih.gov/pubmed/24121065
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2013.09.027
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