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The Role of Alpha-Synuclein Oligomerization and Aggregation in Cellular and Animal Models of Parkinson’s Disease

α-synuclein (α-syn) is a synaptic protein in which four mutations (A53T, A30P, E46K and gene triplication) have been found to cause an autosomal dominant form of Parkinson’s disease (PD). It is also the major component of intraneuronal protein aggregates, designated as Lewy bodies (LBs), a prominent...

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Autors principals: Wan, Oi Wan, Chung, Kenny K. K.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2012
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3373518/
https://ncbi.nlm.nih.gov/pubmed/22701661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0038545
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