TASK1 (K(2P)3.1) K(+) channel inhibition by endothelin-1 is mediated through Rho kinase-dependent phosphorylation

BACKGROUND AND PURPOSE: TASK1 (K(2P)3.1) two-pore-domain K(+) channels contribute substantially to the resting membrane potential in human pulmonary artery smooth muscle cells (hPASMC), modulating vascular tone and diameter. The endothelin-1 (ET-1) pathway mediates vasoconstriction and is an establi...

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Bibliographic Details
Main Authors: Seyler, C, Duthil-Straub, E, Zitron, E, Gierten, J, Scholz, EP, Fink, RHA, Karle, CA, Becker, R, Katus, HA, Thomas, D
Format: Artigo
Language:Inglês
Published: Blackwell Publishing Ltd 2012
Subjects:
Research Papers
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3372730/
https://ncbi.nlm.nih.gov/pubmed/21838752
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2011.01626.x
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