Inhibition of Cardiac Kir Current (I(K1)) by Protein Kinase C Critically Depends on PKCβ and Kir2.2

BACKGROUND: Cardiac inwardly rectifying Kir current (I(K1)) mediates terminal repolarisation and is critical for the stabilization of the diastolic membrane potential. Its predominant molecular basis in mammalian ventricle is heterotetrameric assembly of Kir2.1 and Kir2.2 channel subunits. It has be...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Scherer, Daniel, Seyler, Claudia, Xynogalos, Panagiotis, Scholz, Eberhard P., Thomas, Dierk, Backs, Johannes, Andrassy, Martin, Völkers, Mirko, Karle, Christoph A., Katus, Hugo A., Zitron, Edgar
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4877014/
https://ncbi.nlm.nih.gov/pubmed/27214373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0156181
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