Inhibition of Cardiac Kir Current (I(K1)) by Protein Kinase C Critically Depends on PKCβ and Kir2.2

BACKGROUND: Cardiac inwardly rectifying Kir current (I(K1)) mediates terminal repolarisation and is critical for the stabilization of the diastolic membrane potential. Its predominant molecular basis in mammalian ventricle is heterotetrameric assembly of Kir2.1 and Kir2.2 channel subunits. It has be...

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Publicado en:PLoS One
Main Authors: Scherer, Daniel, Seyler, Claudia, Xynogalos, Panagiotis, Scholz, Eberhard P., Thomas, Dierk, Backs, Johannes, Andrassy, Martin, Völkers, Mirko, Karle, Christoph A., Katus, Hugo A., Zitron, Edgar
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2016
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4877014/
https://ncbi.nlm.nih.gov/pubmed/27214373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0156181
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