Inhibition of Cardiac Kir Current (I(K1)) by Protein Kinase C Critically Depends on PKCβ and Kir2.2

BACKGROUND: Cardiac inwardly rectifying Kir current (I(K1)) mediates terminal repolarisation and is critical for the stabilization of the diastolic membrane potential. Its predominant molecular basis in mammalian ventricle is heterotetrameric assembly of Kir2.1 and Kir2.2 channel subunits. It has be...

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Udgivet i:PLoS One
Main Authors: Scherer, Daniel, Seyler, Claudia, Xynogalos, Panagiotis, Scholz, Eberhard P., Thomas, Dierk, Backs, Johannes, Andrassy, Martin, Völkers, Mirko, Karle, Christoph A., Katus, Hugo A., Zitron, Edgar
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2016
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4877014/
https://ncbi.nlm.nih.gov/pubmed/27214373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0156181
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