Doxazosin induces apoptosis of cells expressing hERG K(+) channels

The antihypertensive drug doxazosin has been associated with an increased risk for congestive heart failure and cardiomyocyte apoptosis. Human ether-a-go-go-related gene (hERG) K(+) channels, previously shown to be blocked by doxazosin at therapeutically relevant concentrations, represent plasma mem...

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Main Authors: Thomas, Dierk, Bloehs, Ramona, Koschny, Ronald, Ficker, Eckhard, Sykora, Jaromir, Kiehn, Johann, Schlömer, Kathrin, Gierten, Jakob, Zitron, Edgar, Scholz, Eberhard P., Kiesecker, Claudia, Katus, Hugo A., Karle, Christoph A.
Format: Artigo
Jezik:Inglês
Izdano: 2007
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2239015/
https://ncbi.nlm.nih.gov/pubmed/18054910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejphar.2007.10.051
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