Inhibition of cardiac HERG currents by the DNA topoisomerase II inhibitor amsacrine: mode of action

1. The topoisomerase II inhibitor amsacrine is used in the treatment of acute myelogenous leukemia. Although most anticancer drugs are believed not to cause acquired long QT syndrome (LQTS), concerns have been raised by reports of QT interval prolongation, ventricular fibrillation and death associat...

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Main Authors: Thomas, Dierk, Hammerling, Bettina C, Wu, Kezhong, Wimmer, Anna-Britt, Ficker, Eckhard K, Kirsch, Glenn E, Kochan, Mary C, Wible, Barbara A, Scholz, Eberhard P, Zitron, Edgar, Kathöfer, Sven, Kreye, Volker A W, Katus, Hugo A, Schoels, Wolfgang, Karle, Christoph A, Kiehn, Johann
Formato: Artigo
Idioma:Inglês
Publicado: 2004
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1574964/
https://ncbi.nlm.nih.gov/pubmed/15148258
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0705795
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