Probenecid: novel use as a non-injurious positive inotrope acting via cardiac TRPV2 stimulation

Probenecid is a highly lipid soluble benzoic acid derivative originally used to increase serum antibiotic concentrations. It was later discovered to have uricosuric effects and was FDA approved for gout therapy. It has recently been found to be a potent agonist of Transient Receptor Potential Vanill...

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Hlavní autoři: Koch, Sheryl E., Gao, Xiaoqian, Haar, Lauren, Jiang, Min, Lasko, Valerie M., Robbins, Nathan, Cai, Wenfeng, Brokamp, Cole, Varma, Priyanka, Tranter, Michael, Liu, Yong, Ren, Xiaoping, Lorenz, John N., Wang, Hong-Sheng, Jones, W. Keith, Rubinstein, Jack
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3372642/
https://ncbi.nlm.nih.gov/pubmed/22561103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2012.04.011
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