Probenecid: novel use as a non-injurious positive inotrope acting via cardiac TRPV2 stimulation

Probenecid is a highly lipid soluble benzoic acid derivative originally used to increase serum antibiotic concentrations. It was later discovered to have uricosuric effects and was FDA approved for gout therapy. It has recently been found to be a potent agonist of Transient Receptor Potential Vanill...

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Detalhes bibliográficos
Main Authors: Koch, Sheryl E., Gao, Xiaoqian, Haar, Lauren, Jiang, Min, Lasko, Valerie M., Robbins, Nathan, Cai, Wenfeng, Brokamp, Cole, Varma, Priyanka, Tranter, Michael, Liu, Yong, Ren, Xiaoping, Lorenz, John N., Wang, Hong-Sheng, Jones, W. Keith, Rubinstein, Jack
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3372642/
https://ncbi.nlm.nih.gov/pubmed/22561103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2012.04.011
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