Probenecid Improves Cardiac Function in Patients With Heart Failure With Reduced Ejection Fraction In Vivo and Cardiomyocyte Calcium Sensitivity In Vitro

BACKGROUND: Transient receptor potential vanilloid 2 is a calcium channel activated by probenecid. Probenecid is a Food and Drug Administration–approved uricosuric drug that has recently been shown to induce positive lusitropic and inotropic effects in animal models through cardiomyocyte transient r...

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Bibliographic Details
Published in:J Am Heart Assoc
Main Authors: Robbins, Nathan, Gilbert, Mark, Kumar, Mohit, McNamara, James W., Daly, Patrick, Koch, Sheryl E., Conway, Ginger, Effat, Mohamed, Woo, Jessica G., Sadayappan, Sakthivel, Rubinstein, Jack
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2018
Subjects:
Original Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5850150/
https://ncbi.nlm.nih.gov/pubmed/29331959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.117.007148
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