Identification of I137M and Other Mutations That Modulate Incubation Periods for Two Human Prion Strains

We report here the transmission of human prions to 18 new transgenic (Tg) mouse lines expressing 8 unique chimeric human/mouse prion proteins (PrP). Extracts from brains of two patients, who died of sporadic Creutzfeldt-Jakob disease (sCJD), contained either sCJD(MM1) or sCJD(VV2) prion strains and...

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Autori principali: Giles, Kurt, De Nicola, Gian Felice, Patel, Smita, Glidden, David V., Korth, Carsten, Oehler, Abby, DeArmond, Stephen J., Prusiner, Stanley B.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2012
Soggetti:
Prions
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3372217/
https://ncbi.nlm.nih.gov/pubmed/22438549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.07027-11
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