Identification of I137M and Other Mutations That Modulate Incubation Periods for Two Human Prion Strains

We report here the transmission of human prions to 18 new transgenic (Tg) mouse lines expressing 8 unique chimeric human/mouse prion proteins (PrP). Extracts from brains of two patients, who died of sporadic Creutzfeldt-Jakob disease (sCJD), contained either sCJD(MM1) or sCJD(VV2) prion strains and...

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Библиографические подробности
Главные авторы: Giles, Kurt, De Nicola, Gian Felice, Patel, Smita, Glidden, David V., Korth, Carsten, Oehler, Abby, DeArmond, Stephen J., Prusiner, Stanley B.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology 2012
Предметы:
Prions
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3372217/
https://ncbi.nlm.nih.gov/pubmed/22438549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.07027-11
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