Identification of I137M and Other Mutations That Modulate Incubation Periods for Two Human Prion Strains

We report here the transmission of human prions to 18 new transgenic (Tg) mouse lines expressing 8 unique chimeric human/mouse prion proteins (PrP). Extracts from brains of two patients, who died of sporadic Creutzfeldt-Jakob disease (sCJD), contained either sCJD(MM1) or sCJD(VV2) prion strains and...

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Detalhes bibliográficos
Main Authors: Giles, Kurt, De Nicola, Gian Felice, Patel, Smita, Glidden, David V., Korth, Carsten, Oehler, Abby, DeArmond, Stephen J., Prusiner, Stanley B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2012
Assuntos:
Prions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3372217/
https://ncbi.nlm.nih.gov/pubmed/22438549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.07027-11
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