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Identification of I137M and Other Mutations That Modulate Incubation Periods for Two Human Prion Strains
We report here the transmission of human prions to 18 new transgenic (Tg) mouse lines expressing 8 unique chimeric human/mouse prion proteins (PrP). Extracts from brains of two patients, who died of sporadic Creutzfeldt-Jakob disease (sCJD), contained either sCJD(MM1) or sCJD(VV2) prion strains and...
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| Главные авторы: | , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Society for Microbiology
2012
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3372217/ https://ncbi.nlm.nih.gov/pubmed/22438549 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.07027-11 |
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