Acidosis Differentially Modulates Inactivation in Na(V)1.2, Na(V)1.4, and Na(V)1.5 Channels

Na(V) channels play a crucial role in neuronal and muscle excitability. Using whole-cell recordings we studied effects of low extracellular pH on the biophysical properties of Na(V)1.2, Na(V)1.4, and Na(V)1.5, expressed in cultured mammalian cells. Low pH produced different effects on different chan...

Full description

Saved in:
Bibliographic Details
Main Authors: Vilin, Yury Y., Peters, Colin H., Ruben, Peter C.
Format: Artigo
Language:Inglês
Published: Frontiers Research Foundation 2012
Subjects:
Pharmacology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3372088/
https://ncbi.nlm.nih.gov/pubmed/22701426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2012.00109
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items