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MTSET modification of D4S6 cysteines stabilize the fast inactivated state of Na(v)1.5 sodium channels
The transmembrane S6 segments of Na(+) sodium channels form the cytoplasmic entrance of the channel and line the internal aspects of the aqueous pore. This region of the channel has been implicated in Na(+) channel permeation, gating, and pharmacology. In this study we utilized cysteine substitution...
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| Veröffentlicht in: | Front Pharmacol |
|---|---|
| Hauptverfasser: | , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Frontiers Media S.A.
2015
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4472985/ https://ncbi.nlm.nih.gov/pubmed/26150789 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2015.00118 |
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