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Cocaine binds to a common site on open and inactivated human heart (Na(v)1.5) sodium channels

The inhibition by cocaine of the human heart Na(+) channel (Na(v)1.5) heterologously expressed in Xenopus oocytes was investigated. Cocaine produced little tonic block of the resting channels but induced a characteristic, use-dependent inhibition during rapid, repetitive stimulation, suggesting that...

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Detalhes bibliográficos
Main Authors: O'Leary, M E, Chahine, M
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2002
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2290378/
https://ncbi.nlm.nih.gov/pubmed/12068034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2001.016139
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