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Cocaine binds to a common site on open and inactivated human heart (Na(v)1.5) sodium channels
The inhibition by cocaine of the human heart Na(+) channel (Na(v)1.5) heterologously expressed in Xenopus oocytes was investigated. Cocaine produced little tonic block of the resting channels but induced a characteristic, use-dependent inhibition during rapid, repetitive stimulation, suggesting that...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Blackwell Science Inc
2002
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| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2290378/ https://ncbi.nlm.nih.gov/pubmed/12068034 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2001.016139 |
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