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Acidosis Differentially Modulates Inactivation in Na(V)1.2, Na(V)1.4, and Na(V)1.5 Channels

Na(V) channels play a crucial role in neuronal and muscle excitability. Using whole-cell recordings we studied effects of low extracellular pH on the biophysical properties of Na(V)1.2, Na(V)1.4, and Na(V)1.5, expressed in cultured mammalian cells. Low pH produced different effects on different chan...

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Autors principals: Vilin, Yury Y., Peters, Colin H., Ruben, Peter C.
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Research Foundation 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3372088/
https://ncbi.nlm.nih.gov/pubmed/22701426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2012.00109
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