Is histone acetylation the most important physiological function for CBP and p300?

Protein lysine acetyltransferases (HATs or PATs) acetylate histones and other proteins, and are principally modeled as transcriptional coactivators. CREB binding protein (CBP, CREBBP) and its paralog p300 (EP300) constitute the KAT3 family of HATs in mammals, which has mostly unique sequence identit...

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Bibliographic Details
Main Authors: Bedford, David C., Brindle, Paul K.
Format: Artigo
Language:Inglês
Published: Impact Journals LLC 2012
Subjects:
Research Perspective
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3371760/
https://ncbi.nlm.nih.gov/pubmed/22511639
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