E2F1 acetylation directs p300/CBP-mediated histone acetylation at DNA double-strand breaks to facilitate repair

E2F1 and retinoblastoma (RB) tumor-suppressor protein not only regulate the periodic expression of genes important for cell proliferation, but also localize to DNA double-strand breaks (DSBs) to promote repair. E2F1 is acetylated in response to DNA damage but the role this plays in DNA repair is unk...

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Publicado no:Nat Commun
Main Authors: Manickavinayaham, Swarnalatha, Vélez-Cruz, Renier, Biswas, Anup K., Bedford, Ella, Klein, Brianna J., Kutateladze, Tatiana G., Liu, Bin, Bedford, Mark T., Johnson, David G.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6821830/
https://ncbi.nlm.nih.gov/pubmed/31666529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-12861-8
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