Binding of the histone chaperone ASF1 to the CBP bromodomain promotes histone acetylation

The multifunctional Creb-binding protein (CBP) protein plays a pivotal role in many critical cellular processes. Here we demonstrate that the bromodomain of CBP binds to histone H3 acetylated on lysine 56 (K56Ac) with higher affinity than to its other monoacetylated binding partners. We show that au...

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Main Authors: Das, Chandrima, Roy, Siddhartha, Namjoshi, Sarita, Malarkey, Christopher S., Jones, David N. M., Kutateladze, Tatiana G., Churchill, Mair E. A., Tyler, Jessica K.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2014
Fag:
PNAS Plus
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3970516/
https://ncbi.nlm.nih.gov/pubmed/24616510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1319122111
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