Targeting histone acetylation dynamics and oncogenic transcription by catalytic P300/CBP inhibition

To separate causal effects of histone acetylation on chromatin accessibility and transcriptional output, we used integrated epigenomic and transcriptomic analyses following acute inhibition of major cellular lysine acetyltransferases P300 and CBP in hematological malignancies. We found that catalyti...

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Publicado no:Mol Cell
Main Authors: Hogg, Simon J., Motorna, Olga, Cluse, Leonie A., Johanson, Timothy M., Coughlan, Hannah D., Raviram, Ramya, Myers, Robert M., Costacurta, Matteo, Todorovski, Izabela, Pijpers, Lizzy, Bjelosevic, Stefan, Williams, Tobias, Huskins, Shannon N., Kearney, Conor J., Devlin, Jennifer R., Fan, Zheng, Jabbari, Jafar S., Martin, Ben P., Fareh, Mohamed, Kelly, Madison J., Dupéré-Richer, Daphné, Sandow, Jarrod J., Feran, Breon, Knight, Deborah, Khong, Tiffany, Spencer, Andrew, Harrison, Simon J., Gregory, Gareth, Wickramasinghe, Vihandha O., Webb, Andrew I., Taberlay, Phillippa C., Bromberg, Kenneth D., Lai, Albert, Papenfuss, Anthony T., Smyth, Gordon K., Allan, Rhys S., Licht, Jonathan D., Landau, Dan A., Abdel-Wahab, Omar, Shortt, Jake, Vervoort, Stephin J., Johnstone, Ricky W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8183601/
https://ncbi.nlm.nih.gov/pubmed/34019788
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2021.04.015
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