Potent and broad neutralization of HIV-1 by a llama antibody elicited by immunization

Llamas (Lama glama) naturally produce heavy chain–only antibodies (Abs) in addition to conventional Abs. The variable regions (VHH) in these heavy chain–only Abs demonstrate comparable affinity and specificity for antigens to conventional immunoglobulins despite their much smaller size. To date, imm...

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Détails bibliographiques
Auteurs principaux: McCoy, Laura E., Quigley, Anna Forsman, Strokappe, Nika M., Bulmer-Thomas, Bianca, Seaman, Michael S., Mortier, Daniella, Rutten, Lucy, Chander, Nikita, Edwards, Carolyn J., Ketteler, Robin, Davis, David, Verrips, Theo, Weiss, Robin A.
Format: Artigo
Langue:Inglês
Publié: The Rockefeller University Press 2012
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3371729/
https://ncbi.nlm.nih.gov/pubmed/22641382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20112655
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