Potent and broad neutralization of HIV-1 by a llama antibody elicited by immunization

Llamas (Lama glama) naturally produce heavy chain–only antibodies (Abs) in addition to conventional Abs. The variable regions (VHH) in these heavy chain–only Abs demonstrate comparable affinity and specificity for antigens to conventional immunoglobulins despite their much smaller size. To date, imm...

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Detalhes bibliográficos
Main Authors: McCoy, Laura E., Quigley, Anna Forsman, Strokappe, Nika M., Bulmer-Thomas, Bianca, Seaman, Michael S., Mortier, Daniella, Rutten, Lucy, Chander, Nikita, Edwards, Carolyn J., Ketteler, Robin, Davis, David, Verrips, Theo, Weiss, Robin A.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3371729/
https://ncbi.nlm.nih.gov/pubmed/22641382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20112655
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