Molecular Evolution of Broadly Neutralizing Llama Antibodies to the CD4-Binding Site of HIV-1

To date, no immunization of humans or animals has elicited broadly neutralizing sera able to prevent HIV-1 transmission; however, elicitation of broad and potent heavy chain only antibodies (HCAb) has previously been reported in llamas. In this study, the anti-HIV immune responses in immunized llama...

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Gepubliceerd in:PLoS Pathog
Hoofdauteurs: McCoy, Laura E., Rutten, Lucy, Frampton, Dan, Anderson, Ian, Granger, Luke, Bashford-Rogers, Rachael, Dekkers, Gillian, Strokappe, Nika M., Seaman, Michael S., Koh, Willie, Grippo, Vanina, Kliche, Alexander, Verrips, Theo, Kellam, Paul, Fassati, Ariberto, Weiss, Robin A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2014
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4270772/
https://ncbi.nlm.nih.gov/pubmed/25522326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1004552
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