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Neutron structure of human carbonic anhydrase II: A hydrogen bonded water network “switch” is observed between pH 7.8 and 10.0

The neutron structure of wild type human carbonic anhydrase II at pH 7.8 has been determined to 2.0 Å resolution. Detailed analysis and comparison to the previously determined structure at pH 10.0 shows important differences in protonation of key catalytic residues in the active site as well as a re...

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Detalhes bibliográficos
Main Authors: Fisher, Zoë, Kovalevsky, Andrey Y., Mustyakimov, Marat, Silverman, David N., McKenna, Robert, Langan, Paul
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3371383/
https://ncbi.nlm.nih.gov/pubmed/21988105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi201487b
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