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Neutron structure of human carbonic anhydrase II: A hydrogen bonded water network “switch” is observed between pH 7.8 and 10.0
The neutron structure of wild type human carbonic anhydrase II at pH 7.8 has been determined to 2.0 Å resolution. Detailed analysis and comparison to the previously determined structure at pH 10.0 shows important differences in protonation of key catalytic residues in the active site as well as a re...
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| 主要な著者: | , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2011
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3371383/ https://ncbi.nlm.nih.gov/pubmed/21988105 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi201487b |
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