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Neutron diffraction of acetazolamide-bound human carbonic anhydrase II reveals atomic details of drug binding

Carbonic anhydrases (CAs) catalyze the hydration of CO(2) forming HCO(3)(−) and a proton, an important reaction for many physiological processes including respiration, fluid secretion, and pH regulation. As such, CA isoforms are prominent clinical targets for treating various diseases. The clinicall...

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Detalhes bibliográficos
Main Authors: Fisher, S. Zoë, Aggarwal, Mayank, Kovalevsky, Andrey Y., Silverman, David N., McKenna, Robert
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3524527/
https://ncbi.nlm.nih.gov/pubmed/22928733
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja3068098
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