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Neutron diffraction of acetazolamide-bound human carbonic anhydrase II reveals atomic details of drug binding
Carbonic anhydrases (CAs) catalyze the hydration of CO(2) forming HCO(3)(−) and a proton, an important reaction for many physiological processes including respiration, fluid secretion, and pH regulation. As such, CA isoforms are prominent clinical targets for treating various diseases. The clinicall...
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| Main Authors: | , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2012
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3524527/ https://ncbi.nlm.nih.gov/pubmed/22928733 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja3068098 |
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