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The Importance of a Critical Protonation State and the Fate of the Catalytic Steps in Class A β-Lactamases and Penicillin-binding Proteins
β -Lactamases and penicillin-binding proteins are bacterial enzymes involved in antibiotic resistance to β-lactam antibiotics and biosynthetic assembly of cell wall, respectively. Members of these large families of enzymes all experience acylation by their respective substrates at an active site ser...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2004
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3371256/ https://ncbi.nlm.nih.gov/pubmed/15152012 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M313143200 |
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