Mutational Replacement of Leu-293 in the Class C Enterobacter cloacae P99 β-Lactamase Confers Increased MIC of Cefepime

The class C β-lactamase from Enterobacter cloacae P99 confers resistance to a wide range of broad-spectrum β-lactams but not to the newer cephalosporin cefepime. Using PCR mutagenesis of the E. cloacae P99 ampC gene, we obtained a Leu-293-Pro mutant of the P99 β-lactamase conferring a higher MIC of...

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Autors principals: Vakulenko, Sergei B., Golemi, Dasantila, Geryk, Bruce, Suvorov, Maxim, Knox, James R., Mobashery, Shahriar, Lerner, Stephen A.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2002
Matèries:
Mechanisms of Resistance
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC127218/
https://ncbi.nlm.nih.gov/pubmed/12019116
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.46.6.1966-1970.2002
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