Mutational Replacement of Leu-293 in the Class C Enterobacter cloacae P99 β-Lactamase Confers Increased MIC of Cefepime

The class C β-lactamase from Enterobacter cloacae P99 confers resistance to a wide range of broad-spectrum β-lactams but not to the newer cephalosporin cefepime. Using PCR mutagenesis of the E. cloacae P99 ampC gene, we obtained a Leu-293-Pro mutant of the P99 β-lactamase conferring a higher MIC of...

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Detalhes bibliográficos

Publicado no:	Antimicrob Agents Chemother
Principais autores:	Vakulenko, Sergei B., Golemi, Dasantila, Geryk, Bruce, Suvorov, Maxim, Knox, James R., Mobashery, Shahriar, Lerner, Stephen A.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 2002
Assuntos:	Mechanisms of Resistance
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC127218/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12019116/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.46.6.1966-1970.2002
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