Mutational Replacement of Leu-293 in the Class C Enterobacter cloacae P99 β-Lactamase Confers Increased MIC of Cefepime

The class C β-lactamase from Enterobacter cloacae P99 confers resistance to a wide range of broad-spectrum β-lactams but not to the newer cephalosporin cefepime. Using PCR mutagenesis of the E. cloacae P99 ampC gene, we obtained a Leu-293-Pro mutant of the P99 β-lactamase conferring a higher MIC of...

Cijeli opis

Spremljeno u:
Bibliografski detalji
Glavni autori: Vakulenko, Sergei B., Golemi, Dasantila, Geryk, Bruce, Suvorov, Maxim, Knox, James R., Mobashery, Shahriar, Lerner, Stephen A.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2002
Teme:
Mechanisms of Resistance
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC127218/
https://ncbi.nlm.nih.gov/pubmed/12019116
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.46.6.1966-1970.2002
Oznake: Dodaj oznaku
Bez oznaka, Budi prvi tko označuje ovaj zapis!

Similar Items