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Mutational Replacement of Leu-293 in the Class C Enterobacter cloacae P99 β-Lactamase Confers Increased MIC of Cefepime

The class C β-lactamase from Enterobacter cloacae P99 confers resistance to a wide range of broad-spectrum β-lactams but not to the newer cephalosporin cefepime. Using PCR mutagenesis of the E. cloacae P99 ampC gene, we obtained a Leu-293-Pro mutant of the P99 β-lactamase conferring a higher MIC of...

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Udgivet i:Antimicrob Agents Chemother
Principais autores: Vakulenko, Sergei B., Golemi, Dasantila, Geryk, Bruce, Suvorov, Maxim, Knox, James R., Mobashery, Shahriar, Lerner, Stephen A.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2002
Fag:
Mechanisms of Resistance
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC127218/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12019116/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.46.6.1966-1970.2002
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