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Class C β-Lactamases Operate at the Diffusion Limit for Turnover of Their Preferred Cephalosporin Substrates

It has been suggested that class C β-lactamases have evolved to carry out a metabolic reaction other than hydrolysis of β-lactam antibiotics. It is demonstrated in the present study that the class C β-lactamase from Enterobacter cloacae P99 has reached the diffusion limit in its ability to hydrolyze...

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Autors principals: Bulychev, Alexey, Mobashery, Shahriar
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 1999
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC89354/
https://ncbi.nlm.nih.gov/pubmed/10390233
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