Roles of β-Lactamases and Porins in Activities of Carbapenems and Cephalosporins against Klebsiella pneumoniae

Two clinical isolates of extended-spectrum β-lactamase (ESBL)-producing Klebsiella pneumoniae were noted to be less susceptible than expected to imipenem. Both were missing outer membrane proteins that serve as channels for antibiotic entry. The role of β-lactamase in resistance was investigated by...

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Bibliographische Detailangaben
Hauptverfasser: Martínez-Martínez, Luis, Pascual, Alvaro, Hernández-Allés, Santiago, Alvarez-Díaz, Dolores, Suárez, Ana Isabel, Tran, John, Benedí, Vicente Javier, Jacoby, George A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 1999
Schlagworte:
Mechanisms of Resistance
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC89341/
https://ncbi.nlm.nih.gov/pubmed/10390220
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