Roles of β-Lactamases and Porins in Activities of Carbapenems and Cephalosporins against Klebsiella pneumoniae

Two clinical isolates of extended-spectrum β-lactamase (ESBL)-producing Klebsiella pneumoniae were noted to be less susceptible than expected to imipenem. Both were missing outer membrane proteins that serve as channels for antibiotic entry. The role of β-lactamase in resistance was investigated by...

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Detalhes bibliográficos

Publicado no:	Antimicrob Agents Chemother
Principais autores:	Martínez-Martínez, Luis, Pascual, Alvaro, Hernández-Allés, Santiago, Alvarez-Díaz, Dolores, Suárez, Ana Isabel, Tran, John, Benedí, Vicente Javier, Jacoby, George A.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1999
Assuntos:	Mechanisms of Resistance
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC89341/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10390220/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.43.7.1669
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