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Structural Consequences of the Inhibitor-Resistant Ser130Gly Substitution in TEM β-Lactamase

β-Lactamase confers resistance to penicillin-like antibiotics by hydrolyzing their β-lactam bond. To combat these enzymes, inhibitors covalently cross-linking the hydrolytic Ser70 to Ser130 were introduced. In turn, mutant β-lactamases have emerged with decreased susceptibility to these mechanism-ba...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Thomas, Veena L., Golemi-Kotra, Dasantila, Kim, Choonkeun, Vakulenko, Sergei B., Mobashery, Shahriar, Shoichet, Brian K.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2005
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1382196/
https://ncbi.nlm.nih.gov/pubmed/15981999
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi0502700
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