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Structural Consequences of the Inhibitor-Resistant Ser130Gly Substitution in TEM β-Lactamase
β-Lactamase confers resistance to penicillin-like antibiotics by hydrolyzing their β-lactam bond. To combat these enzymes, inhibitors covalently cross-linking the hydrolytic Ser70 to Ser130 were introduced. In turn, mutant β-lactamases have emerged with decreased susceptibility to these mechanism-ba...
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| Главные авторы: | , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2005
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1382196/ https://ncbi.nlm.nih.gov/pubmed/15981999 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi0502700 |
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