The Importance of a Critical Protonation State and the Fate of the Catalytic Steps in Class A β-Lactamases and Penicillin-binding Proteins

β -Lactamases and penicillin-binding proteins are bacterial enzymes involved in antibiotic resistance to β-lactam antibiotics and biosynthetic assembly of cell wall, respectively. Members of these large families of enzymes all experience acylation by their respective substrates at an active site ser...

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Hlavní autoři: Golemi-Kotra, Dasantila, Meroueh, Samy O., Kim, Choonkeun, Vakulenko, Sergei B., Bulychev, Alexey, Stemmler, Ann J., Stemmler, Timothy L., Mobashery, Shahriar
Médium: Artigo
Jazyk:Inglês
Vydáno: 2004
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3371256/
https://ncbi.nlm.nih.gov/pubmed/15152012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M313143200
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