Genotype and Subtype Profiling of PSI-7977 as a Nucleotide Inhibitor of Hepatitis C Virus

PSI-7977, a prodrug of 2′-F-2′-C-methyluridine monophosphate, is the purified diastereoisomer of PSI-7851 and is currently being investigated in phase 3 clinical trials for the treatment of hepatitis C. In this study, we profiled the activity of PSI-7977 and its ability to select for resistance usin...

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Autores principales: Lam, Angela M., Espiritu, Christine, Bansal, Shalini, Micolochick Steuer, Holly M., Niu, Congrong, Zennou, Veronique, Keilman, Meg, Zhu, Yuao, Lan, Shuiyun, Otto, Michael J., Furman, Phillip A.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2012
Materias:
Antiviral Agents
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3370800/
https://ncbi.nlm.nih.gov/pubmed/22430955
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00054-12
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