Suppression of Spermatogenesis by Bisdichloroacetyldiamines Is Mediated by Inhibition of Testicular Retinoic Acid Biosynthesis

The bisdichloroacetyldiamine WIN 18,446 reversibly inhibits spermatogenesis in many species, including humans; however, the mechanism by which WIN 18,446 functions is unknown. As retinoic acid is essential for spermatogenesis, we hypothesized that WIN 18,446 might inhibit retinoic acid biosynthesis...

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Main Authors: Amory, John K., Muller, Charles H., Shimshoni, Jakob A., Isoherranen, Nina, Paik, Jisun, Moreb, Jan S., Amory, David W., Evanoff, Ryan, Goldstein, Alex S., Griswold, Michael D.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3370679/
https://ncbi.nlm.nih.gov/pubmed/20705791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2164/jandrol.110.010751
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