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X-ray Structures of Progesterone Receptor Ligand Binding Domain in Its Agonist State Reveal Differing Mechanisms for Mixed Profiles of 11β-Substituted Steroids

We present here the x-ray structures of the progesterone receptor (PR) in complex with two mixed profile PR modulators whose functional activity results from two differing molecular mechanisms. The structure of Asoprisnil bound to the agonist state of PR demonstrates the contribution of the ligand t...

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Bibliografske podrobnosti
Main Authors: Lusher, Scott J., Raaijmakers, Hans C. A., Vu-Pham, Diep, Kazemier, Bert, Bosch, Rolien, McGuire, Ross, Azevedo, Rita, Hamersma, Hans, Dechering, Koen, Oubrie, Arthur, van Duin, Marcel, de Vlieg, Jacob
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2012
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3370215/
https://ncbi.nlm.nih.gov/pubmed/22535964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.308403
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