X-ray Structures of Progesterone Receptor Ligand Binding Domain in Its Agonist State Reveal Differing Mechanisms for Mixed Profiles of 11β-Substituted Steroids

We present here the x-ray structures of the progesterone receptor (PR) in complex with two mixed profile PR modulators whose functional activity results from two differing molecular mechanisms. The structure of Asoprisnil bound to the agonist state of PR demonstrates the contribution of the ligand t...

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Hlavní autoři: Lusher, Scott J., Raaijmakers, Hans C. A., Vu-Pham, Diep, Kazemier, Bert, Bosch, Rolien, McGuire, Ross, Azevedo, Rita, Hamersma, Hans, Dechering, Koen, Oubrie, Arthur, van Duin, Marcel, de Vlieg, Jacob
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2012
Témata:
Protein Structure and Folding
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3370215/
https://ncbi.nlm.nih.gov/pubmed/22535964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.308403
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