Engineered Troponin C Constructs Correct Disease-related Cardiac Myofilament Calcium Sensitivity

Aberrant myofilament Ca(2+) sensitivity is commonly observed with multiple cardiac diseases, especially familial cardiomyopathies. Although the etiology of the cardiomyopathies remains unclear, improving cardiac muscle Ca(2+) sensitivity through either pharmacological or genetic approaches shows pro...

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Hlavní autoři: Liu, Bin, Lee, Ryan S., Biesiadecki, Brandon J., Tikunova, Svetlana B., Davis, Jonathan P.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2012
Témata:
Molecular Bases of Disease
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3370186/
https://ncbi.nlm.nih.gov/pubmed/22511780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.334953
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