Rhodanine and Thiohydantoin Derivatives for Detecting Tau Pathology in Alzheimer’s Brains

[Image: see text] A novel series of rhodanin (RH) and thiohydantoin (TH) derivatives were designed and synthesized for detecting tau pathology in the brains of patients with Alzheimer’s disease (AD). In experiments in vitro using tau and β-amyloid (Aβ) aggregates, the TH derivative, TH2, showed high...

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Main Authors: Ono, Masahiro, Hayashi, Shun, Matsumura, Kenji, Kimura, Hiroyuki, Okamoto, Yoko, Ihara, Masafumi, Takahashi, Ryosuke, Mori, Hiroshi, Saji, Hideo
Format: Artigo
Jezik:Inglês
Izdano: American Chemical Society 2011
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3369744/
https://ncbi.nlm.nih.gov/pubmed/22778869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cn200002t
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