The “Specific” P-Glycoprotein Inhibitor Tariquidar Is Also a Substrate and an Inhibitor for Breast Cancer Resistance Protein (BCRP/ABCG2)

[Image: see text] Tariquidar was developed as a specific inhibitor of the efflux transporter ABCB1. Recent positron emission tomographic brain imaging studies using [(11)C]tariquidar to measure ABCB1 (P-gp, P-glycoprotein) density in mice indicate that the inhibitor may not be as specific as previou...

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Detalhes bibliográficos
Main Authors: Kannan, Pavitra, Telu, Sanjay, Shukla, Suneet, Ambudkar, Suresh V., Pike, Victor W., Halldin, Christer, Gottesman, Michael M., Innis, Robert B., Hall, Matthew D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2010
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3369725/
https://ncbi.nlm.nih.gov/pubmed/22778859
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cn100078a
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