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Tariquidar Is an Inhibitor and Not a Substrate of Human and Mouse P-glycoprotein
Since its development, tariquidar (TQR; XR9576; N-[2-[[4-[2-(6,7-Dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]phenyl]carbamoyl]-4,5-dimethoxyphenyl]quinoline-3-carboxamide) has been widely regarded as one of the more potent inhibitors of P-glycoprotein (P-gp), an efflux transporter of the ATP-bin...
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| Vydáno v: | Drug Metab Dispos |
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| Hlavní autoři: | , , , , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
The American Society for Pharmacology and Experimental Therapeutics
2016
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4746486/ https://ncbi.nlm.nih.gov/pubmed/26658428 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.115.067785 |
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