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Tariquidar Is an Inhibitor and Not a Substrate of Human and Mouse P-glycoprotein

Since its development, tariquidar (TQR; XR9576; N-[2-[[4-[2-(6,7-Dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]phenyl]carbamoyl]-4,5-dimethoxyphenyl]quinoline-3-carboxamide) has been widely regarded as one of the more potent inhibitors of P-glycoprotein (P-gp), an efflux transporter of the ATP-bin...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Drug Metab Dispos
Egile Nagusiak: Weidner, Lora D., Fung, King Leung, Kannan, Pavitra, Moen, Janna K., Kumar, Jeyan S., Mulder, Jan, Innis, Robert B., Gottesman, Michael M., Hall, Matthew D.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: The American Society for Pharmacology and Experimental Therapeutics 2016
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4746486/
https://ncbi.nlm.nih.gov/pubmed/26658428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.115.067785
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