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Pharmacokinetics of single ascending doses of the P-glycoprotein inhibitor tariquidar in healthy subjects
We assessed the pharmacokinetics (PK), tolerability and safety of tariquidar (TQD), a P-glycoprotein (Pgp) inhibitor, after i.v. administration of single ascending doses. Employed doses were up to 4-fold higher than in previous clinical trials in cancer patients and are capable to inhibit Pgp at the...
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| Hlavní autoři: | , , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2012
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3689924/ https://ncbi.nlm.nih.gov/pubmed/23146816 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000343243 |
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