The Inhibitor Ko143 Is Not Specific for ABCG2

Imaging ATP-binding cassette (ABC) transporter activity in vivo with positron emission tomography requires both a substrate and a transporter inhibitor. However, for ABCG2, there is no inhibitor proven to be specific to that transporter alone at the blood-brain barrier. Ko143 [[(3S,6S,12aS)-1,2,3,4,...

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Detalhes bibliográficos
Publicado no:J Pharmacol Exp Ther
Main Authors: Weidner, Lora D., Zoghbi, Sami S., Lu, Shuiyu, Shukla, Suneet, Ambudkar, Suresh V., Pike, Victor W., Mulder, Jan, Gottesman, Michael M., Innis, Robert B., Hall, Matthew D.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2015
Assuntos:
Chemotherapy, Antibiotics, and Gene Therapy
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4538874/
https://ncbi.nlm.nih.gov/pubmed/26148857
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.115.225482
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